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. 2024 Jan 17;67(2):1225–1242. doi: 10.1021/acs.jmedchem.3c01714

Table 4. In Vivo PK Data in Rats: Compound 14 and 20.

compd In vivo PK rat
14 CLblood = 0.50 L/h/kg, t1/2 = 2.9 h, Vss = 1.6 L/kg, F = 41%
20 CLblood = 0.31 L/h/kg, t1/2 = 2.9 h, Vss = 1.3 L/kg, F = 46%