Table 7. Comparison of Matched Pairs Based on Indazole and Benzimidazole Core.
Biochemical potency of IRAK4 inhibition (1 mM ATP).
Biochemical potency of FLT3 inhibition (10 μM ATP).
Compound purity ap. 90% according to 1H NMR.
,eResults for the individual enantiomers with unkown absolute stereochemistry.