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. 2024 Jan 29;19:94. doi: 10.1186/s13018-024-04578-2

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A Venn Diagram depicting number of differentially expressed genes in bone and tissue and the number of overlapping genes, up-expressed genes are in red and down-expressed genes in blue; DEG – differentially expressed genes. B Heatmap of the top 20 differentially expressed genes in bone samples with logFC >|2.0| ranked by adj-P value. C Volcano plot of differentially expressed genes in bone samples. D Heatmap of top 80 differentially expressed genes in tissue samples with logFC >|2.0| ranked by adj-P value. E Volcano plot of differentially expressed genes in tissue samples, the top three up or down-expressed mRNA genes are labelled