Table 5.

Differentially expressed miRNA and their gene targets based on C2 pathways

miRNA	Target tissue	Pathway	Gene	Direction	Adj-P	logFC
miR-1246	Bone	Wnt	FZD7	Up	0.0038	2.1
	Bone	Wnt	PRKCB	Down	0.0032	-2.5
	Bone	Wnt	DIXDC1	Up	0.0007	4.0
	Bone	Wnt	SFRP4	Up	0.0014	3.6
	Bone	Inflammation	TGFB3	Up	0.0014	2.4
	Bone	TGFB	TGFB3	Up	0.0014	2.4
	Bone	Wnt	FSTL1	Up	0.0037	2.4
miR-574-3p	Bone	JAK-STAT	IL6	Up	0.0080	2.4
miR-6089	Bone	Wnt	RAC2	Down	0.0089	− 2.3
	Bone	Wnt	FRAT2	Down	0.0059	− 2.2
	Bone	Wnt	DIXDC1	Up	0.0008	4.0
	Bone	Wnt	WNT9A	Up	0.0021	2.4