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. 2024 Jan 28;22:41. doi: 10.1186/s12951-024-02298-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Strategies and applications of exosome-enhanced immunotherapy. A Engineered exosomes for cancer immunotherapy. Reproduced with permission. [178] Copyright 2020, Wiley. B HEK293-derived exosomes loaded with R848 (immunoadjuvant) and Ce6 (sonosensitizer) promoted DC2.4 maturation. (I) ExoR848 + Ce6 intervention DC2.4 schematic diagram. (ii) Western blot analysis of Hsp70 in DC2.4 from different treatment groups. (iii) The production of ROS in the different treatment group DC2.4 (scale = 100 microns) and statistical analysis. (iv) Flow cytometry and statistical analysis of CD80 and CD86 expression in DC2.4 of different treatment groups. Reproduced with permission. [140] Copyright 2022, Informa UK Limited