Fig. 7.

Distribution characteristics and pharmacokinetics of exosomes in vivo. A DiR/DiI-labeled exosomes were injected intraperitoneally or intravenously into mice to monitor the distribution of exosomes in vivo. B Ex vivo fluorescence images (i) and quantification plots (ii) of vital organs and tumor sites in mice after intraperitoneal or intravenous injection of DiR/DiI-labeled exosomes. (iii) Distribution of DiR/DiI-labeled exosomes at tumor sites. Scale bar = 100 μm. C After the exosomes loaded with cel-miR54 were injected intraperitoneally or intravenously into mice, (i) the distribution of exosomes in vivo and (ii) the expression of cel-miR54 in important organs and tumor sites in mice. Reproduced with permission. [140] Copyright 2022, Informa UK Limited. D Distribution of DiR-labeled exosomes in vital organs of tumor-bearing and non-tumor-bearing mice (i) and (ii) accumulation of exosomes at tumor sites 24 or 48 h after intraperitoneal injection. Reproduced with permission. [145] Copyright 2020, Wiley