Fig. 5.

Relative changes in intracellular metabolite levels during ethanol and isobutanol exposure. Only metabolites exhibiting a greater than 1.5 change (in either direction) with a P value of < 0.05 during exposure to either ethanol or isobutanol are shown. Each row corresponds to a single metabolite. Alterations in metabolite levels are displayed as log2-fold changes relative to unexposed controls, red indicates high relative metabolite levels and blue indicates low relative metabolite levels. The data shown represents the average of three independent biological replicates. Abbreviations: MEP, 2-C-methyl-d-erythritol 4-phosphate; cMEPP, 2-C-methyl-d-erythritol 2,4-cyclodiphosphate; DMAPP, dimethylallyl diphosphate; IPP, isopentenyl diphosphate; DXP, 1-deoxy-d-xylulose 5-phosphate; HMBPP, 4-hydroxy-3-methylbut-2-enyl diphosphate; CDP-MEP, 4-diphosphocytidyl-2-C-methyl-d-erythritol 2-phosphate; KDPG, 2-dehydro-3-deoxy-d-gluconate 6-phosphate