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. 2024 Jan 29;19:13. doi: 10.1186/s13024-023-00690-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Deleting NMNAT2 in cortical glutamatergic neurons results in Amyloid Precursor Protein (APP) accumulation (A, B, C) Representative confocal microscopy images showing APP accumulation in multiple brain regions of ctrl and cKO mice at P5 and P21. Scale bars, 50 um for all left panels, 100 um for all right panels. Dashed white lines mark the margins of corpus callosum (A) and fimbria (B). D High magnification image showing that the accumulated APP is encircled by myelin sheath labeled by myelin basic protein (MBP) staining in P16 cKO corpus callosum (observed in 3 out of 3 cKO brains). E Quantification of the APP signal in the corpus callosum, hippocampal fimbria, and striatum area of cKO mice normalized to the average signal in ctrl mice at P5 and P21. Number of mice: P5, 3–6 ctrl, and 3–6 cKO; P16/P21 3–6 ctrl and 3–4 cKO. Unpaired t-test and Mann–Whitney test were applied for the statistic result, *p < 0.05, **p < 0.01, ***p < 0.001