Table 2.
Hazard ratio (95% confidence interval) | ||||
---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 4 | |
TyG (continuous) | P for interaction < 0.001 | P for interaction < 0.001 | P for interaction < 0.001 | P for interaction < 0.001 |
Total | 0.98 (0.88–1.09) | 1.10 (0.98–1.23) | 1.11 (0.99–1.25) | 1.00 (0.88–1.14) |
< 65 yrs |
1.47 (1.22–1.76)* P < 0.001 |
1.50 (1.24–1.81)* P < 0.001 |
1.48 (1.23–1.79)* P < 0.001 |
1.33 (1.06–1.66)* P = 0.014 |
≥ 65 yrs | 0.89 (0.77–1.02) | 0.94 (0.81–1.08) | 0.98 (0.85–1.13) | 0.91 (0.78–1.12) |
TyG (categorical) | P for interaction < 0.001 | P for interaction < 0.001 | P for interaction < 0.001 | P for interaction < 0.001 |
TyG tertile 1 | Reference | Reference | Reference | Reference |
Total | ||||
TyG tertile 2 |
0.79 (0.66–0.94)* P = 0.008 |
0.80 (0.67–0.96)* P = 0.014 |
0.89 (0.74–1.06) |
0.83 (0.69–0.99)* P = 0.043 |
TyG tertile 3 | 0.92 (0.78–1.08) | 1.06 (0.90–1.26) | 1.12 (0.94–1.33) | 0.96 (0.79–1.16) |
< 65 yrs | ||||
TyG tertile 2 | 0.96 (0.67–1.38) | 0.92 (0.64–1.31) | 1.02 (0.71–1.47) | 0.97 (0.67–1.40) |
TyG tertile 3 |
1.57 (1.15–2.14)* P = 0.005 |
1.56 (1.14–2.14)* P = 0.005 |
1.66 (1.20–2.30)* P = 0.002 |
1.40 (1.03–1.99)* P = 0.046 |
≥ 65 yrs | ||||
TyG tertile 2 |
0.71 (0.58–0.87)* P < 0.001 |
0.81 (0.66–0.99)* P < 0.043 |
0.90 (0.73–1.10) | 0.84 (0.68–1.04) |
TyG tertile 3 | 0.83 (0.67–1.01) | 0.90 (0.74–1.11) | 0.96 (0.78–1.19) | 0.87 (0.69–1.09) |
Model 1 was unadjusted
Model 2 was adjusted for age and gender
Model 3 was adjusted for age, gender, ethnicity, BMI, CHF, CAD, albumin, LDL-C, eGFR, UACR, Insulin treatment, and metformin
Model 4 was adjusted for age, gender, ethnicity, educational level, current smoking, BMI, CHF, CAD, hypertension, albumin, LDL-C, eGFR, HbA1c, UACR, UA, Insulin treatment, metformin, and statins
*indicated that the p value was less than 0.05