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. 2024 Jan 28;23:43. doi: 10.1186/s12933-024-02120-6

Table 2.

Association between TyG and all-cause mortality

Hazard ratio (95% confidence interval)
Model 1 Model 2 Model 3 Model 4
TyG (continuous) P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001
 Total 0.98 (0.88–1.09) 1.10 (0.98–1.23) 1.11 (0.99–1.25) 1.00 (0.88–1.14)
 < 65 yrs

1.47 (1.22–1.76)*

P < 0.001

1.50 (1.24–1.81)*

P < 0.001

1.48 (1.23–1.79)*

P < 0.001

1.33 (1.06–1.66)*

P = 0.014

 ≥ 65 yrs 0.89 (0.77–1.02) 0.94 (0.81–1.08) 0.98 (0.85–1.13) 0.91 (0.78–1.12)
TyG (categorical) P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001
  TyG tertile 1 Reference Reference Reference Reference
 Total
  TyG tertile 2

0.79 (0.66–0.94)*

P = 0.008

0.80 (0.67–0.96)*

P = 0.014

0.89 (0.74–1.06)

0.83 (0.69–0.99)*

P = 0.043

  TyG tertile 3 0.92 (0.78–1.08) 1.06 (0.90–1.26) 1.12 (0.94–1.33) 0.96 (0.79–1.16)
 < 65 yrs
  TyG tertile 2 0.96 (0.67–1.38) 0.92 (0.64–1.31) 1.02 (0.71–1.47) 0.97 (0.67–1.40)
  TyG tertile 3

1.57 (1.15–2.14)*

P = 0.005

1.56 (1.14–2.14)*

P = 0.005

1.66 (1.20–2.30)*

P = 0.002

1.40 (1.03–1.99)*

P = 0.046

 ≥ 65 yrs
  TyG tertile 2

0.71 (0.58–0.87)*

P < 0.001

0.81 (0.66–0.99)*

P < 0.043

0.90 (0.73–1.10) 0.84 (0.68–1.04)
  TyG tertile 3 0.83 (0.67–1.01) 0.90 (0.74–1.11) 0.96 (0.78–1.19) 0.87 (0.69–1.09)

Model 1 was unadjusted

Model 2 was adjusted for age and gender

Model 3 was adjusted for age, gender, ethnicity, BMI, CHF, CAD, albumin, LDL-C, eGFR, UACR, Insulin treatment, and metformin

Model 4 was adjusted for age, gender, ethnicity, educational level, current smoking, BMI, CHF, CAD, hypertension, albumin, LDL-C, eGFR, HbA1c, UACR, UA, Insulin treatment, metformin, and statins

*indicated that the p value was less than 0.05