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. 2024 Jan 28;23:43. doi: 10.1186/s12933-024-02120-6

Table 3.

Association between TyG and non-cardiovascular mortality

Hazard ratio (95% confidence interval)
Model 1 Model 2 Model 3 Model 4
TyG (continuous) P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001 P for interaction < 0.001
 Total 0.98 (0.86–1.11) 1.09 (0.95–1.25) 1.09 (0.95–1.25) 1.05 (0.90–1.22)
 < 65 yrs

1.55 (1.25–1.94)*

P < 0.001

1.59 (1.27-2.00)*

P < 0.001

1.60 (1.28-2.00)*

P < 0.001

1.54 (1.18–2.01)*

P < 0.002

 ≥ 65 yrs 0.85 (0.72–1.01) 0.90 (0.76–1.06) 0.91 (0.77–1.08) 0.92 (0.76–1.12)
TyG (categorical) P for interaction = 0.002 P for interaction = 0.002 P for interaction < 0.001 P for interaction = 0.001
  TyG tertile 1 Reference Reference Reference Reference
 Total
  TyG tertile 2

0.79 (0.64–0.98)*

P = 0.032

0.81 (0.65–0.99)*

P = 0.045

0.87 (0.70–1.07) 0.84 (0.68–1.05)
  TyG tertile 3 0.92 (0.75–1.12) 1.06 (0.87–1.30) 1.07 (0.87–1.32) 1.01 (0.81–1.27)
 < 65 yrs
  TyG tertile 2 0.94 (0.61–1.43) 0.89 (0.58–1.36) 0.98 (0.63–1.51) 0.93 (0.60–1.45)
  TyG tertile 3

1.55 (1.07–2.24)*

P = 0.020

1.54 (1.07–2.24)*

P = 0.021

1.64 (1.12–2.41)*

P = 0.011

1.44 (1.01–2.18)*

P = 0.048

 ≥ 65 yrs
  TyG tertile 2

0.72 (0.56–0.92)*

P = 0.008

0.82 (0.64–1.04) 0.87 (0.68–1.12) 0.87 (0.67–1.12)
  TyG tertile 3 0.82 (0.64–1.05) 0.90 (0.70–1.15) 0.92 (0.71–1.18) 0.94 (0.71–1.34)

Model 1 was unadjusted

Model 2 was adjusted for age and gender

Model 3 was adjusted for age, gender, ethnicity, educational level, BMI, CHF, albumin, eGFR, UACR, insulin treatment, and metformin

Model 4 was adjusted for age, gender, ethnicity, educational level, current smoking, BMI, CHF, CAD, hypertension, albumin, LDL-C, eGFR, HbA1c, UACR, UA, Insulin treatment, metformin, and statins

*indicated that the p value was less than 0.05