FIGURE 8.

DEC3‐AmB‐LLs were efficient at inhibiting and/or killing two of the three fungal pathogens examined. Candida albicans, Rhizopus delemar, and Cryptococcus neoformans were grown in 96‐well microtiter plates and treated with DEC3‐AmB‐LLs, AmB‐LLs, and BSA‐AmB‐LLs, delivering the indicated micromolar concentrations of AmB. Growth inhibition and/or killing were assayed as reductions in cell density measured at A₆₁₀ or reductions in viable cell metabolic activity by measuring the electrochemical reduction of the redox dye resazurin in CellTiter‐Blue reagent to fluorescent resorufin after liposome treatment. (a) Residual metabolic activity of C. albicans. (b) Cell density of R. delemar. (c) Residual metabolic activity of R. delemar. (d) Residual metabolic activity of C. neoformans. Cell density and metabolic activity are shown in scatter bar plots. N = 5 to 8 for each bar. Standard errors from the mean and p or P_MW values are indicated.