Table 3.

Study flow charts of study procedures

Time point	Baseline	Enrolment	Follow-up
Visit	Screening	1	2	3	4
Time	1–3 days before surgery	POD 1	POD 5	POD 14	POD35
Screening and enrolment
Patient information	×
Inclusion/exclusion criteria	×	×
Informed consent	×
Demographics	×
Medical history	×
Allocation of drugs		×
Assessments
Vital signs	×	×	×	×	×
CBC	×	×	×	×	×
Iron status	×	×	×	×	×
Reticulocyte analysis	×	×	×	×	×
Urinalysis	×	×
Liver and renal function tests	×	×
Coagulation tests	×	×
EQ-5D-3L		×	×	×	×
FACIT-fatigue		×	×	×	×
Barthel Index		×	×	×	×
Others
Adverse events		×	×	×	×
Combined medication		×	×	×	×
Distribution of drugs		×
Recovery of drugs					×
Compliance judgement					×

CBC, complete blood count; EQ-5D-3L, EuroQol-5 Dimension-3 Levels; FACIT-fatigue, Functional Assessment of Chronic Illness Therapy – Fatigue Scale; POD, postoperative day.