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. 2024 Jan 25;12(1):e008138. doi: 10.1136/jitc-2023-008138

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Chordomas display hallmarks of antitumor immunity. (A) Heatmap demonstrating the log2 normalized gene expression Z-score of the top 200 most variably expressed genes in all sarcoma samples (n=59). Samples are annotated according to their histotype. Genes associated with chordoma samples are highlighted on the right. These genes include chordoma-specific genes such as TBXT, CD24 and several keratins. In addition, immune-related genes are highlighted, including human leukocyte antigen (HLA*) and immunoglobulin (IG*) genes. (B) Heatmap presenting the Z-score for the log2 normalized expression of the 20 ICR signature genes in 20 chordoma samples. Based on the expression Z-score, the samples are classified into two groups through unsupervised hierarchical clustering: ICR high (n=17) and ICR low (n=3). (C) Boxplots presenting the immunologic constant of rejection (ICR) score per sarcoma subtype in descending order. (D) Kaplan-Meier curves displaying disease-specific survival for the ICR high and ICR low chordomas. Two-sided log-rank tests were performed for the Kaplan-Meier estimates. ECM, extracellular matrix; USTS, undifferentiated soft tissue sarcoma.