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. Author manuscript; available in PMC: 2024 Jan 29.
Published in final edited form as: J Thromb Haemost. 2023 Apr 15;21(8):2236–2247. doi: 10.1016/j.jtha.2023.04.008

Figure 2:

Figure 2:

Role of αIIbβ3 integrin activation and ligand binding in TEG. Blood samples were analyzed from WT mice (n=8) or mice with megakaryocyte/platelet-specific deletion of Talin1 (Tln1mKO, n=5). αIIbβ3 ligand binding was inhibited by treating WT samples with anti-αIIbβ3 antibody (Leo.H4, 75 μg/ml, n=6) for 10 mins prior to TEG assay. (A-C) TEG parameters: R time (A), α-angle (B) and MA (C). (D) Representative TEG traces. Data shown as mean ± SD. Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparison test. Symbols directly over bars represent significance compared to control. **P< .01, ***P<0.001, ****P < .0001.