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. Author manuscript; available in PMC: 2024 Jan 29.
Published in final edited form as: J Thromb Haemost. 2023 Apr 15;21(8):2236–2247. doi: 10.1016/j.jtha.2023.04.008

Figure 3:

Figure 3:

Role of Rap1 GTPase signaling in TEG. Blood samples were analyzed from WT mice (n=8), mice with global deficiency in CalDAG-GEFI and P2Y12 (Cdg1−/− × P2ry12−/−, n=4) or mice with megakaryocyte/platelet-specific deletion of Rap1b alone (Rap1bmKO, n=4) or both Rap1a and Rap1b (Rap1a/bmKO, n=5). (A-C) TEG parameters: R time (A), α-angle (B) and MA (C). (D) Representative TEG traces. Data shown as mean ± SD. Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparison test. Symbols directly over bars represent significance compared to control. **P< .01, ***P<0.001, ****P < .0001.