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. Author manuscript; available in PMC: 2024 Jul 17.
Published in final edited form as: Clin Cancer Res. 2024 Jan 17;30(2):444–449. doi: 10.1158/1078-0432.CCR-23-0602

Table 1:

Collapsed classifier groups and pathologic response outcomes, pooled treatment arms

Classifier # patients Complete response, pT0N0 n (%; 95% CI) Downstaging* (<pT2N0) n (%; 95% CI)
Total 155 51 (33%; 26%, 41%) 81 (52%; 44%, 60%)
TCGA
 Basal/Sq + Neuronal

55

21 (38%; 25%, 52%)

26 (47%; 34%, 61%)
 Luminal 77 25 (33%; 22%, 44%) 43 (56%; 44%, 67%)
 Luminal infiltrated 23 5 (22%; 7%, 44%) 12 (52%; 31%, 73%)
Consensus
 Ba, Sq, NE

51

17 (33%; 21%, 48%)

24 (47%; 33%, 62%)
 Luminal 80 27 (34%; 24%, 45%) 46 (58%; 46%, 68%)
 Stroma-rich 24 7 (29%; 13%, 51%) 11 (46%; 26%, 67%)
MDA
 Basal

49

14 (29%; 17%, 43%)

23 (47%; 33%, 62%)
 Luminal 56 22 (39%; 27%, 53%) 36 (64%; 50%, 77%)
 p53-like 50 15 (30%; 18%, 45%) 22 (44%; 30%, 59%)
*

Downstaging category includes complete responders

TCGA – The Cancer Genome Atlas, Ba – Basal, Sq – Squamous, NE – neuroendocrine, MDA – MD Anderson