Table 4:
Classifier | N/# deaths/# PFS events | 5-yr PFS estimate | PFS HR (95% CI), p-value* | 5-yr OS estimate | OS HR (95% CI), p-value* |
---|---|---|---|---|---|
TCGA | |||||
Basal/Sq/Neuronal | 55/17/24 | 57% | 1.0 (reference) | 72% | 1.0 (reference) |
Luminal | 77/19/28 | 63% | 0.68(0.40, 1.18), P=0.17 | 75% | 0.67 (0.35, 1.29), p=0.23 |
Luminal inf. | 23/6/7 | 67% | 0.58 (0.25, 1.36), P=0.21 | 72% | 0.84 (0.33, 2.13) p=0.71 |
Consensus | |||||
Ba/Sq/NE | 51/15/21 | 60% | 1.0 (reference) | 74% | 1.0(reference) |
Luminal | 80/20/29 | 63% | 0.75 (0.43, 1.31), P=0.31 | 75% | 0.73 (0.37, 1.43) p=0.36 |
Stroma-rich | 24/7/9 | 61% | 0.84 (0.38, 1.85), P=0.67 | 69% | 1.03 (0.42, 2.55) p=0.95 |
MDA | |||||
Basal | 49/14/19 | 62% | 1.0 (reference) | 75% | 1.0 (reference) |
Luminal | 56/14/20 | 65% | 0.81 (0.43, 1.52), P=0.51 | 75% | 0.73 (0.35, 1.55) p=0.41 |
p53-like | 50/14/20 | 57% | 0.99 (0.53, 1.86), P=0.98 | 70% | 0.97 (0.46, 2.03) p=0.93 |
adjusted for two stratification factors, 2-sided p value