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. 2023 Jun 27;124(2):135–148. doi: 10.1055/s-0043-1769735

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 3 — The ( A ) effectiveness and ( B ) safety compared between individual NOAC types in AF patients with polypharmacy (≥5 concomitantly used drugs) after IPTW. The weighted number of subjects at risk in the pseudo-population, weighted number of events, weighted event rates per 100 PY, and adjusted HRs with 95% CIs after IPTW are illustrated. aHR, adjusted hazard ratio; CI, confidence interval; HR, hazard ratio; IPTW, inverse probability of treatment weighting; NOAC, non-vitamin K antagonist oral anticoagulant; PY, person-years; Ref, reference category; SE, systemic embolism.