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. 2023 Oct 30;5(1):47–65. doi: 10.1038/s43018-023-00653-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Targeted lipidomics analysis on 593 lipid species and their desaturation levels. a, PCA plot on normalized peak areas of lipid species in FADS2-edited (FADS2-sg1, FADS2-sg2) or non-edited (empty-vector control) NB4 cultures supplemented for 24h with either 4 microM imetelstat or vehicle control. b,c, Differential enrichment analysis using lipidR tool of unsaturated bonds in all measured lipid species (b), and lipid species according to lipid classes (c). Red box plots denote significantly different comparisons with P < 5 × 10⁻³. N = 3 independent replicates per condition from distinct cell passages. Lipid classes: Acylcarnitines (AcylCarnitine), Cholesteryl ester (CE), Ceramide (Cer), Desmosterol (DE), Diacylglycerol (DG), Dihydroceramide (dhCer), GM1 ganglioside (GM1), GM3 ganglioside (GM3), Dihexosylceramide (Hex2Cer), Trihexosylcermide (Hex3Cer), Monohexosylceramide (HexCer), Lysophosphatidylcholine (LPC), Lysoalkylphosphatidylcholine (LPCO), Lysoalkenylphosphatidylcholine (LPCP), Lysophosphatidylethanolamine (LPE), Lysoalkenylphosphatidylethanolamine (LPEP), Lysophosphatidylinositol (LPI), Phosphatidylcholine (PC), Phosphatidylethanolamine (PE), Phosphatidylglycerol (PG), Phosphatidylinositol (PI), Phosphatidylserine (PS), Sphingomyelin (SM), Sphingosine (Sph), Sulfatide (Sulfatide), Triacylglycerol (TG), Alkyldiacylglycerol (TGO). NA: Molecules which could not be parsed by lipidr (for example ubiquinone, free cholesterol).

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