Supplementary Table S4.

Features of the Cytokines and Chemokines that are Upregulated by IL-36

Gene	Fold Up-Regulation in Primary Keratinocytes Treated with1			Upregulated in GPP skin2	Downregulated by GPP treatment
	IL-36α	IL-36β	IL-36γ	-	Skin3	Blood4
IL36G	17.7	23.8	21.4	Yes	Yes	No
CXCL1	7.8	9.2	9.9	Yes	Yes	Yes
CCL20	7.6	9.0	9.2	Yes	No	No
CXCL8	7.0	8.5	8.8	Yes	Yes	Yes
IL32	5.6	5.7	5.6	No	No	Yes
IL1B	5.1	5.0	5.3	Yes	Yes	Yes
CXCL5	2.6	3.8	3.4	No	Yes	No
IL36RN	2.5	3.8	3.2	Yes	No	No
CXCL3	2.5	3.3	2.9	No	Yes	Yes
CXCL2	2.6	3.0	2.9	Yes	Yes	No
IL1A	2.8	2.3	2.5	No	No	No
IL24	2.6	2.2	2.6	No	Yes	No
IL23A	2.2	2.6	2.5	Yes	Yes	No
CXCL16	2.3	2.6	2.4	No	No	No
IL20	2.3	2.0	2.3	Yes	Yes	No

Abbreviation: GPP, generalized pustular psoriasis.

¹Cultured keratinocytes (Mahil et al., 2017).

²GPP vs healthy skin (Baum et al., 2022).

³GPP skin sampled before and after treatment with spesolimab (Baum et al., 2022).

⁴GPP peripheral blood mononuclear cells sampled before and after treatment with acitretin (Wang et al., 2018).