Table 4.

Logistic regression model evaluating relation of laboratory parameters with ACS

	OR			aOR
ACS	OR	95% CI	P	OR	95% CI	P
Pediatric cohort
PoS (10 mmHg ↑)	1.73	1.24-2.42	.001∗	1.55	1.08-2.19	.015
EImin (0.1 EI ↑)	0.51	0.35-0.72	<.0001∗	0.59	0.41-0.85	.007
EImax (0.1 EI ↑)	0.61	0.42-0.89	.009∗	0.70	0.48-1.01	.059
Blood viscosity (1.0 cP ↑)†	0.85	0.59-1.21	.364	0.78	0.53-1.14	.195
HVR	0.94	0.62-1.41	.750	1.00	0.65-1.53	.984
Hb (1.0 g/dL↑)	0.99	0.80-1.23	.925	0.98	0.78-1.22	.841
HbF (10.0% ↑)‡	0.50	0.29-0.86	.011∗	0.57	0.31-1.04	.068
MCV (10 fl ↑)	1.26	0.99-1.59	.061	1.17	0.91-1.51	.200
MCHC (1.0 g/dL ↑)	1.05	0.83-1.33	.665	1.09	0.85-1.38	.509
MCH (10.0 pg ↑)	1.13	0.56-2.28	.739	0.81	0.40-1.64	.584
ARC (100 × 109/L ↑)	1.19	0.97-1.45	.097	1.16	0.94-1.43	.165
DRBCs (1.0% ↑)	1.19	1.07-1.32	.002∗	1.14	1.02-1.27	.019
Adult cohort
PoS (10 mmHg ↑)	1.65	0.90-3.03	.104	1.52	0.81-2.85	.190
EImin (0.1 EI ↑)	0.53	0.22-1.25	.144	0.62	0.26-1.47	.268
EImax (0.1 EI ↑)	0.73	0.34-1.53	.388	0.87	0.40-1.90	.723
Blood viscosity (1.0 cP ↑)	n/a	n/a	n/a	n/a	n/a	n/a
HVR	n/a	n/a	n/a	n/a	n/a	n/a
Hb (1.0 g/dL ↑)	1.12	0.67-1.87	.679	1.12	0.67-1.87	.666
HbF (10.0% ↑)	0.96	0.53-1.73	.902	1.20	0.72-2.74	.597
MCV (10 fl ↑)	1.06	0.73-1.54	.744	1.21	0.80-1.83	.370
MCHC (1.0 g/dL ↑)	1.06	0.67-1.67	.811	1.08	0.68-1.72	.748
MCH (1.0 pg ↑)	1.02	0.93-1.12	.671	1.05	0.94-1.18	.383
ARC (100 ×109 per L ↑)	1.06	0.56-2.03	.847	0.97	0.48-1.97	.925
DRBCs (1.0% ↑)	n/a	n/a	n/a	n/a	n/a	n/a

A logistic regression analysis was performed to calculate ORs for oxygen gradient ektacytometry–derived parameters, blood viscosity, DRBCs, HbF, and hemocytometry parameters in relation to occurrence of ACS. aORs were corrected for age and hydroxyurea therapy.

Abbreviations are explained in Table 3.

^∗OR is significant after correcting for multiple testing (false discovery rate analysis).

^†Data of 110 individuals available.

^‡Data of 90 individuals available.