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. 2024 Jan 30;16:9. doi: 10.1038/s41368-023-00267-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cell communications in different metabolic regions of tumor tissues. Heatmap showing the counts of cell-cell communication between different cell types in the three metabolic regions. a Cell data deconvolution and b SC data deconvolution. The red and blue boxes indicate the communication between fibroblast-T (CD4 T) and Epithelial-fibroblast in hypermetabolic and hypometabolic regions, respectively. The blue box indicates changes in the communication of fibroblasts. c Intersection of predicted ligands from Cell data and SC data through Nichenet analysis. d Intersection of predicted target genes for the predicted ligands from Cell data and SC data through Nichenet analysis. The 7 target genes were used as the target panel below