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. 2024 Jan 27;56(1):2. doi: 10.1007/s00726-023-03370-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The Spearman’s rho (a, c) and Pearson (b, d) similarity indices were used in combination with the Fruchterman–Reingold algorithm as a force-directed layout algorithm in the network analysis. This method constructs a network based on the frequency with which nodes are linked. The panels show the most closely related amino acid/s metabolism in cumulus-oocyte complexes during in vitro maturation to (a, b) blastocyst rate and cleavage rate or (c, d) heat shock. Blast blastocyst rate, Cleav cleavage rate