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The potential sources of intratumoral microbiota. (A) Hematogenous spread facilitates the infiltration of intratumor microbes from oral, intestinal, and other sources into tumor sites. (B) Microbiota can disrupt the mucosal barrier and infiltrate tumor sites, and intratumoral microbiota of cancer may infiltrate tumor sites via the duct. (C) Normal adjacent tissue may provide a source for intratumor microbiota. Graphics created with BioRender.com.
