Table 2B | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
% Blasts pre-LD | Allo-SCT Pre-CART |
First absolute B-cell count (%) | Months after infusion Absolute loss BCA |
Months after infusion Loss BCA Pennsyl |
Months after infusion >1% B-cell at BM | Clinical decision after loss BCA | Relapse (Months after infusion) |
Duration of remission since loss of BCA (months) | Intervention after relapse | Allo-SCT post CAR-T (Indication) |
Last follow up (months after infusion) | |
1 | 0 | Yes | 9 (0,15) | 9 | 11 | 9 | Wait and see | No | Ongoing | No | Alive (34) | |
2 | 0 | Yes | 168 (20) | 8 | 8 | 9 | Wait and see | Yes (11) | 3 | Inotuzumab + reinfusion | No | Death (progression) |
3 | 0 | Yes | 15 (0,5) | 6 | 7 | 6 | Wait and see Asp-PEG |
Yes (16) | 10 | Inotuzumab | No | Alive. Palliative care (16) |
4 | 0,01 | No | 20 (2) | 6 | 6 | Not reached | Wait and see | Yes (7) | 1 (MRD relapse) |
CART dual + Allo-SCT | Yes (relapse) |
Alive (36) |
5 | 0,46 | Yes | 22 (0,3) | 8 | 8 | 6 | Wait and see | No | Ongoing | No | Alive (27) | |
6 | 0 | Yes | 476 (14) | 14 | 14 | 9 | Wait and see | Yes (23) | 9 | Reinfusion | No | Alive. Palliative care (46) |
7 | 0,03 | Yes | 111 (3) | 18 | 18 | 12 | Wait and see | No | Ongoing | No | Alive (42) | |
8 | 0,27 | No | 28 (7) | 7 | 7 | 6 | 1° Allo-SCT | Yes (26) | 19 | Inotuzumab + 2° Allo-SCT | Yes (loss BCA) |
Alive. Recent 2° Allo- SCT (26) |
9 | 0,5 | No | 72 (4) | 24 | 24 | 24 | Wait and see | Yes (28) | 4 | Chemotherapy Waiting for 1° Allo-SCT |
Yes (relapse) |
Alive with disease (29) |