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. 2024 Jan 16;14:1280580. doi: 10.3389/fimmu.2023.1280580
Table 2B
% Blasts pre-LD Allo-SCT
Pre-CART
First absolute B-cell count (%) Months after infusion
Absolute loss BCA
Months after infusion
Loss BCA Pennsyl
Months after infusion >1% B-cell at BM Clinical decision after loss BCA Relapse
(Months after infusion)
Duration of remission since loss of BCA (months) Intervention after relapse Allo-SCT post CAR-T
(Indication)
Last follow up (months after infusion)
1 0 Yes 9 (0,15) 9 11 9 Wait and see No Ongoing No Alive (34)
2 0 Yes 168 (20) 8 8 9 Wait and see Yes (11) 3 Inotuzumab + reinfusion No Death (progression)
3 0 Yes 15 (0,5) 6 7 6 Wait and see
Asp-PEG
Yes (16) 10 Inotuzumab No Alive. Palliative care (16)
4 0,01 No 20 (2) 6 6 Not reached Wait and see Yes (7) 1
(MRD relapse)
CART dual + Allo-SCT Yes
(relapse)
Alive (36)
5 0,46 Yes 22 (0,3) 8 8 6 Wait and see No Ongoing No Alive (27)
6 0 Yes 476 (14) 14 14 9 Wait and see Yes (23) 9 Reinfusion No Alive. Palliative care (46)
7 0,03 Yes 111 (3) 18 18 12 Wait and see No Ongoing No Alive (42)
8 0,27 No 28 (7) 7 7 6 1° Allo-SCT Yes (26) 19 Inotuzumab + 2° Allo-SCT Yes
(loss BCA)
Alive.
Recent 2° Allo- SCT (26)
9 0,5 No 72 (4) 24 24 24 Wait and see Yes (28) 4 Chemotherapy
Waiting for 1° Allo-SCT
Yes
(relapse)
Alive with disease
(29)