Figure 3.

Improved glucose tolerance and insulin sensitivity in ETB-deficient mice. (A) Time course of blood glucose concentration following i.p. injection of glucose (2 g/kg body weight) in overnight-fasted wild type mice (etb^+/+) and etb^−/− mice before (upper panel; n = 8 per group) and after 4 weeks of feeding a HFD (lower panel; n = 5 per group). (B) Time course of blood glucose levels (n = 4 per group) in etb^+/+ and etb^−/− mice on normal diet that had been fasted for 4 h and received an i.p. injection of insulin (1.5 IU/kg body weight). (C) Serum insulin levels (n = 7–8 per group) in 4-h-fasted etb^+/+ and etb^−/− mice on normal diet. All parameters are given as arithmetic means ± SEM. ∗p < 0.05 and ∗∗p < 0.01 indicate significant difference between the genotypes. (A and B: two-tailed unpaired Student's t test; C: Mann–Whitney U test).