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ETB-deficient mice exhibit elevated serum levels of endothelin 1. Arithmetic means ± SEM (n = 6 per group) of the serum endothelin 1 (ET-1) concentration in wild type (etb+/+) and etb−/− mice on normal diet. ∗∗p < 0.01 indicates significant difference between etb+/+ and etb−/− mice. (Mann–Whitney U test).
