TABLE 3.
Parameter estimates in the final models for overall survival and progression-free survival.
| Parameter | Estimates | RSE (%) | 95% CI | |
|---|---|---|---|---|
| Overall survival | λ | 12.0 | 4.13 | 11.028–12.972 |
| γ | 3.67 | 3.13 | 3.445–3.895 | |
| EMAX | 0.704 | 3.98 | 0.649–0.759 | |
| EC50 (μg/mL) | 77.5 | 2.80 | 73.247–81.753 | |
| HILL | 20 | — | — | |
| Progression-free survival | λ | 8.28 | 7.97 | 6.986–9.574 |
| γ | 3.94 | 9.19 | 3.230–4.650 | |
| EMAX | 0.451 | 28.82 | 0.196–0.706 | |
| EC50 (μg/mL) | 77.7 | 5.08 | 69.958–85.442 | |
| HILL | 20 | — | — |
λ and γ are scale and shape factors, respectively, in the log-logistic model.
Emax, maximum inhibitory effect; EC50, steady-state trough concentrations at half of Emax; HILL, Hill coefficient in the sigmoid maximum effect model; RSE%, relative standard error; CI, confidence interval.