Table 1.

Microparameters used to define regional TACs for six theoretical VOIs included in the simulations

Microparameters	VOI 1a	VOI 2b	VOI 3c	VOI 4d	VOI 5a	VOI 6d	Average (WB)e
$K_1$(mL/g/min)	0.105	0.123	0.096	0.088	0.069	0.062	0.090
$k_2$(min−1)	0.148	0.121	0.109	0.123	0.129	0.071	0.117
$k_3$(min−1)	0.074	0.079	0.042	0.071	0.064	0.067	0.066
$V_b$(mL/g)	0.050f	0.059	0.050f	0.084	0.050d	0.050	0.067
$K_i$(mL/g/min)	0.035	0.049	0.027	0.032	0.023	0.030	0.033

^aBased on the work of Reivich et al. [35]

^bBased on the work of Sari et al. [9]

^cBased on the work of Zanotti-Fregonara et al. [36]

^dBased on the work of Huisman et al. [37]

^eWB TAC was obtained by using the average microparameters

^fCBV was not reported

CBV Cerebral blood volume; TACs Time-activity curve; VOI Volume-of-interest; WB Whole brain