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. 2023 Dec 13;23(1):100696. doi: 10.1016/j.mcpro.2023.100696

Fig. 1.

Fig. 1

Schematic overview of Plg/Plm structures and putative post-translational modifications. Activation of full-length Glu-Plg occurs by the cleavage of the activation site at R561. The conversion of Glu-Plg to Lys-Plg occurs through the cleavage of an N-terminal peptide. Plg and thus also Plm can harbor up to two core O-glycans (S249 and T346) and one complex N-glycan (N289). The N-glycan site is not always occupied, which has led to the classical distinction between type I (occupied) and type II Plg/Plm. Amino acids are numbered without the signal peptide. Plg, plasminogen; Plm, plasmin.