Skip to main content
. 2023 Oct 27;13(1):2–20. doi: 10.12997/jla.2024.13.1.2

Fig. 2. Action of apoC3 in lipoprotein metabolism. ApoC3 inhibits lipoprotein lipase and inhibits the liver uptake of remnants and LDL particles by the LDLR or LRP1, and possibly SDC1 and SRB1, by interfering with the binding of apoE to those receptors. It may also stimulate release of VLDL particles from the liver. When LPL activity is absent, inhibition of apoC3 facilitates hepatic uptake of particles by the LDLR and LRP1.

Fig. 2

ApoC3, apolipoprotein C3; CM, chylomicron; CMR, chylomicron remnant; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; LPL, lipoprotein lipase; LRP1, LDLR-related protein 1; SDC1, syndecan-1; SR-B1, scavenger receptor B1; VLDL, very low-density lipoprotein.