Table 5.
Local adverse reactions after the first/single dose of MVA-BN vaccination according to previous smallpox vaccination and odds ratio of experiencing reaction of each grade in the 121 participants who fulfilled the symptoms diary.
| Local reactions | Vaccine-experienced (N = 58) | Vaccine- naïve (N = 63) | p-valuea | Adj ORb (CI 95%) | p-valuec |
|---|---|---|---|---|---|
| Redness | 41 (70.7) | 48 (76.2) | 0.028 | ||
| Absent | 17 (29.3) | 15 (23.8) | 1 | ||
| Mild | 13 (22.4) | 17 (27.1) | 0.69 (0.25–1.89) | 0.47 | |
| Moderate | 15 (25.9) | 21 (33.3) | 0.011 | 0.66 (0.25–1.73) | 0.40 |
| Severe | 13 (22.4) | 10 (15.9) | 1.15 (0.40–3.40) | 0.80 | |
| Induration | 38 (65.5) | 50 (79.4) | 0.006 | ||
| Absent | 20 (34.5) | 13 (20.6) | 1 | ||
| Mild | 21 (36.2) | 24 (38.1) | 0.57 (0.23–1.43) | 0.23 | |
| Moderate | 8 (13.8) | 18 (28.6) | 0.004 | 0.30 (0.10–0.88) | 0.03 |
| Severe | 9 (15.5) | 8 (12.7) | 0.76 (0.23–2.46) | 0.64 | |
| Pain | 38 (65.5) | 50 (79.4) | 0.003 | ||
| Absent | 20 (34.5) | 13 (20.6) | 1 | ||
| Mild | 31 (53.4) | 31 (49.2) | 0.6 (0.25–1.44) | 0.25 | |
| Moderate | 4 (6.9) | 13 (20.6) | 0.001 | 0.19 (0.05–0.73) | 0.01 |
| Severe | 3 (5.2) | 6 (9.5) | 0.31 (0.06–1.48) | 0.14 |
a
Chi-square test.
b
Odds ratio for the vaccine-experienced to develop adverse reaction compared to vaccine-naïve.
c
Logistic regression model adjusted for HIV.