Table 6.
Duration of systemic and local adverse reactions according to previous smallpox vaccination.
| Systemic reactions | Duration of reactions |
||||
|---|---|---|---|---|---|
| Duration (days) |
p-valuea | ||||
| Smallpox vaccine-experienced |
Smallpox vaccine-naïve |
||||
| Mean Median |
SD IQR |
Mean Median |
SD IQR |
||
| Chills | |||||
| At least mild | 2.7 2.0 |
3.2 1.0, 3.0 |
1.4 1.0 |
0.7 1.0, 1.5 |
0.0533 |
| Moderate or severe | 2.2 1.0 |
2.9 1.0, 2.0 |
1.0 1.0 |
1.0, 1.0 | <0.0001 |
| Nausea | |||||
| At least mild | 2.5 1.0 |
3.4 1.0, 2.0 |
2.1 1.0 |
1.5 1.0, 3.0 |
0.4654 |
| Moderate or severe | 1.9 1.0 |
2.4 1.0, 2.0 |
1.7 1.0 |
1.2 1.0, 3.0 |
0.8703 |
| Vomit | |||||
| At least mild | 2.3 1.0 |
3.4 1.0, 2.0 |
|||
| Muscle pain | |||||
| At least mild | 3.7 2.0 |
4.1 1.0, 4.0 |
3.1 3.0 |
1.9 1.0, 4.0 |
0.5815 |
| Moderate or severe | 2.8 2.0 |
3.2 1.0, 3.0 |
2.1 2.0 |
1.5 1.0, 3.0 |
0.2590 |
| Fatigue | |||||
| At least mild | 4.3 3.0 |
4.9 1.0, 5.0 |
3.0 2.0 |
2.0 1.0, 4.0 |
0.4824 |
| Moderate or severe | 2.7 2.0 |
3.2 1.0, 3.0 |
2.2 1.0 |
1.9 1.0, 3.0 |
0.1394 |
| Headache | |||||
| At least mild | 3.1 2.0 |
3.6 1.0, 4.0 |
2.0 1.0 |
1.7 1.0, 2.0 |
0.7115 |
| Moderate or severe | 2.2 1.0 |
2.8 1.0, 2.0 |
2.1 1.0 |
2.3 1.0, 3.0 |
0.5709 |
| Local Reactions | |||||
| Redness | |||||
| At least mild | 16.7 17.0 |
9.4 9.0, 27.0 |
14.6 13.5 |
10.0 5.5, 24.5 |
0.2898 |
| Moderate or severe | 6.3 5.0 |
5.5 2.0, 9.0 |
6.3 4.0 |
7.0 2.0, 5.0 |
0.8982 |
| Induration | |||||
| At least mild | 14.0 12.0 |
9.2 6.0, 22.0 |
12.9 9.5 |
9.9 5.0, 23.0 |
0.5496 |
| Moderate or severe | 5.4 3.0 |
5.2 2.0, 7.0 |
4.0 3.0 |
4.0 2.0, 4.0 |
0.4702 |
| Local pain | |||||
| At least mild | 6.4 5.0 |
5.4 2.0, 8.0 |
4.3 4.5 |
2.8 2.0, 6.0 |
0.1168 |
| Moderate or severe | 3.9 3.0 |
3.9 1.0, 5.0 |
2.5 2.0 |
1.4 1.0, 3.0 |
0.2651 |
Analysis was performed for each symptom of any grade and for each symptom of grades 3–4 (moderate or severe).
a
Unpaired t-test.