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. 2005 Apr;71(4):1971–1976. doi: 10.1128/AEM.71.4.1971-1976.2005

FIG. 6.

FIG. 6.

FKBP12 binding of novel rapamycin analogs, expressed as percent inhibition of 3H-labeled FK506-FKBP12 (control) complex formation. (A) Binding of 20-thiarapamycin to FKBP12 was reduced 33-fold compared to binding of rapamycin. The IC50 of the rapamycin control was 1.6 nM, and the IC50 of 20-thiarapamycin was 53.6 nM. (B) Binding of 15-deoxo-19-sulfoxylrapamycin to FKBP12 was reduced 166-fold compared to binding of rapamycin. The IC50 of the rapamycin control was 4.9 nM, and the IC50 of 15-deoxo-19-sulfoxylrapamycin was 800 nM.