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. 2023 Dec 22;6(1):e220127. doi: 10.1148/rycan.220127

Figure 2:

Region-specific assessment of intracellular pH (pHi) alterations over all study participants with glioma (n = 12). Box plots of mean pHi values in normal-appearing white matter (NAWM), whole-tumor volume (WTV), and subvolumes of interest (necrosis, gadolinium enhancement [GDCE], nonenhancing T2 hyperintensity [NCE T2]) in all participants with high-grade glioma (HGG) (World Health Organization grade III–IV, n = 8). The pHi of the WTV was increased compared with that of NAWM in all participants (P < .001). Analysis of tumor subregions yielded increased mean pHi values for subvolumes of interest compared with NAWM (P < .01). The pHi in necrosis and GDCE was increased compared with NCE T2 (necrosis, P = .02; GDCE, P = .02), with no evidence of differences between the other tumor subcompartments. Mean pHi values for all study participants and subvolumes are shown (gray circles). The red line in the middle of each box is the sample median. The bottom and top of each box are the 25th and 75th percentiles of the sample, respectively. The distance between the bottom and top of each box is the IQR. The whiskers of the box plots extend from the ends of the box to the smallest and largest data values.

Region-specific assessment of intracellular pH (pHi) alterations over all study participants with glioma (n = 12). Box plots of mean pHi values in normal-appearing white matter (NAWM), whole-tumor volume (WTV), and subvolumes of interest (necrosis, gadolinium enhancement [GDCE], nonenhancing T2 hyperintensity [NCE T2]) in all participants with high-grade glioma (HGG) (World Health Organization grade III–IV, n = 8). The pHi of the WTV was increased compared with that of NAWM in all participants (P < .001). Analysis of tumor subregions yielded increased mean pHi values for subvolumes of interest compared with NAWM (P < .01). The pHi in necrosis and GDCE was increased compared with NCE T2 (necrosis, P = .02; GDCE, P = .02), with no evidence of differences between the other tumor subcompartments. Mean pHi values for all study participants and subvolumes are shown (gray circles). The red line in the middle of each box is the sample median. The bottom and top of each box are the 25th and 75th percentiles of the sample, respectively. The distance between the bottom and top of each box is the IQR. The whiskers of the box plots extend from the ends of the box to the smallest and largest data values.