Nonlinear regression fitting was performed on the dissolution results of INM at various temperatures, using eqn (1). The concentration of INM released immediately after dissolution (C0), the saturated concentration of INM (CS), the product of the dissolution rate constant and the effective surface area of powder particles (kS), and the sum of squared residuals (SS) were listed.
α-Form | γ-Form | |||||||
---|---|---|---|---|---|---|---|---|
C 0/mM | C S/mM | kS/min−1 | SS | C 0/mM | C S/mM | kS/min−1 | SS | |
278 K | 0.16 ± 0.12 | 0.63 ± 0.01 | 0.17 ± 0.05 | 6.6 × 10−4 | 0.07 ± 0.06 | 0.39 ± 0.02 | 0.10 ± 0.04 | 9.4 × 10−4 |
298 K | 0.23 ± 0.10 | 1.45 ± 0.03 | 0.18 ± 0.04 | 6.2 × 10−3 | 0.13 ± 0.04 | 1.01 ± 0.05 | 0.20 ± 0.05 | 6.7 × 10−4 |
313 K | 0.32 ± 0.08 | 2.45 ± 0.18 | 0.14 ± 0.04 | 2.4 × 10−2 | 0.15 ± 0.05 | 1.78 ± 0.16 | 0.14 ± 0.07 | 5.2 × 10−2 |