Table 7.
Reference; Study Confidence Rating; N | Exposure | Outcome transformation | Effect estimate | MIBP median (ng/mL) | Sperm concentration (×106/ml) | Motility (% normal) | Morphology (% normal) |
---|---|---|---|---|---|---|---|
Thurston et al. (2016); Medium; 420 | Ln-transformed | Log-transformed | β (CI) | 2.8 | 0.02 (−0.06,0.11) | 0.82 (−0.31,1.96) | 0.28 (−0.27,0.83) |
Bloom et al. (2015); Medium; 375 | Continuous ln transformed; 1 IQR difference | Box-Cox transformed | β (CI) | 4.4 | 0.46 (−1.90,2.83) | −0.98 (−3.16,1.20) | −4.43 (−15.15,6.29) |
Den Hond et al. (2015); Low; 120 | Continuous ln-transformed | Continuous, no transformation noted | β (SE) | 55 (mean) | 0.16 (0.53) | 4.81 (3.59) | 0.10 (0.33) |
(Pan et al., 2016); Pan et al. (2015); Medium; 1,066 | Ln-transformed | Cubic root for conc | % change (CI) | 48 | −2.1% (−4.6,0.4) | −2.2% (−5.4,1.1) | −5.3% (−8.9,−1.8)* |
p < 0.05, results that support an association are shaded. Dark gray represents one or more of the following: p < 0.05, large effect size (e.g., OR ≥ 1.5, β ≥ −0.5, % difference ≥ 1.0%), or exposure-response trend across categories of exposure. Light gray represents other supportive results.
Q = quartile; T = tertile. Studies are sorted by study confidence level within each metabolite-effect estimate grouping.