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. 2024 Jan 30;21:36. doi: 10.1186/s12974-024-03028-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Improvement of meningeal lymphatics alleviates sepsis-induced cognitive dysfunction in aged mice. A The experimental timeline of the intracisternal AAV infusion, LPS treatment, behavioral test, tracer injection into the cisterna magna, and tissue collection (sac). B Representative images depicting eGFP (green)-labeled AAV1-infected cells surrounding Lyve1 (red)⁺ meningeal lymphatics, scale bars: 1 mm. C Representative immunofluorescence images of meningeal whole-mounts of OVA-647 stained with Lyve-1. D Graph depicting the percentage area of Lyve-1 coverage in the meningeal lymphatic vasculature, n = 6. E Graph depicting the percentage area of OVA-647 coverage in the meningeal lymphatic vasculature, n = 6. F Representative immunofluorescent images of OVA-647 accumulation in dCLNs. G Graph depicting the percentage area of OVA-647 coverage in the dCLNs, n = 6. H Representative trajectory of each group in the FCT. I Quantitative of freezing time in the FCT, n = 8. **P < 0.01. All data are expressed as the mean ± SD