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. 2024 Jan 30;21:36. doi: 10.1186/s12974-024-03028-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Improvement in meningeal lymphatics reduces sepsis-induced expression of disease-associated genes in aged mice. A Principal component (PC) analysis showing clustering of samples. B Volcano plots illustrate the number of significantly differentially expressed genes. C Heatmap representation of the top 20 most significantly upregulated and downregulated (FDR < 0.1) genes in the eGFP + LPS group vs. VEGF-C + LPS group. D KEGG pathway analysis of upregulated genes in the VEGF-C + LPS group compared to the eGFP + LPS group. E KEGG pathway analysis of downregulated genes in the VEGF-C + LPS group compared to the eGFP + LPS group