Table 2.

Comparison of plasma bone markers between sex

Variables	Sex-by-time interaction		Time main effect		Sex main effect
	F	p	F	p	F	p
MARDS	1.334	0.266	178.535	< 0.001	0.118	0.732
DKK1	0.086	0.918	5.714	0.004	0.120	0.730
Leptin	4.134	0.017	34.487	< 0.001	50.361	< 0.001
OPG	1.028	0.360	12.147	< 0.001	0.002	0.965
OC	4.317	0.015	131.300	< 0.001	3.048	0.084
OPN	2.485	0.086	99.487	< 0.001	0.298	0.586
SOST	4.726	0.010	66.668	< 0.001	1.220	0.272
PTH	0.637	0.530	36.864	< 0.001	1.447	0.232
FGF23	0.490	0.613	36.980	< 0.001	0.785	0.378

BMI: body mass index; MADRS: Montgomery–Asberg Depression Rating Scale; DKK1: Dickkopf-related protein 1; OPG: osteoprotegerin; OC: osteocalcin; OPN: osteopontin; SOST: sclerostin; PTH: parathyroid hormone; FGF23: fibroblast growth factor 23