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. 2024 Jan 30;24:47. doi: 10.1186/s12935-024-03240-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Decreased Expression of LINC00894 in PTC Tissues and Cells. (A) Relative LINC00894 expression in normal thyroid tissue, PTC tissue without lymphatic metastasis, and PTC tissue with lymphatic metastasis using GEO (GSE60542). (B) Venn diagram showing the overlapping differentially expressed lncRNAs, depending on A1 and A2. (C) Assessment of LINC00894 expression in normal thyroid tissue, PTC tissue without lymphatic metastasis, and PTC tissue with lymphatic metastasis (PTC-LNM) using TCGA data. (D) Assessment of LINC00894 expression in normal thyroid tissue using the Genotype-Tissue Expression (GTEx) database. (E) Assessment of LINC00894 expression in normal and tumour tissues using the Gene Expression Profiling Interactive Analysis (GEPIA) database. (F) Assessment of LINC00894 expression in THCA based on TCGA data. (G) Assessment of LINC00894 expression in THCA using GEPIA data. (H) QRT-PCR analysis of LINC00894 expression levels in PTC cell lines. (I) Analysis of the clinical impacts of abnormal LINC00894 expression on PTC patient overall survival using Kaplan‒Meier Plotter. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001