Table 1.
Functional and representative inhibitors of metabolic targets
| Targeting molecules | Function | Agents |
|---|---|---|
| GLS1 | Metabolize glutamine into glutamate | CB-839 [37], LWG-301, IPN60090 |
| ASCT2 | Transport neutral amino acids | V9302 [38], SN40, SN02 |
| LAT1 | Transport neutral amino acids | BCH [39], KMH-233, GPNA hydrochloride |
| GLUT1 | Transport glucose | BAY-876, WZB117, STF-31 [40] |
| GLUT4 | Transport glucose, insulin dependent | Fasentin [41], GLUT4-IN-2 |
| MCT1 | Transport and import lactate | BAY-8002, AZD3965 [42] |
| MCT4 | Transport and export lactate | VB124, Syrosingopine [43], AZD0095 |
| PFK-2 | Catalyze fructose-2,6-bisphosphate | PFK-015 [44] |
| FASN | Synthesize fatty acid | TVB-2640, UCM05, Trans-C75 |
| ACC | Catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA | TOFA [45], ND-646 |
| CPT1 | Catalyze the transport of long-chain fatty acids into mitochondria | Etomoxir [46] |
| Mitochondrial Complex I | The major entry point for electrons into the respiratory chain | IACS-010759 [47], DX2-201, HQNO, SCAL-266 |