Altered body composition and glucose metabolism in 5xFADxTg30 mice
(A and B) Body weight, (C and D) lean mass and (E and F) fat mass over time in male and female mice. Male animals n = 6–8 per group, female animals, n = 6–7 per group. Data assessed by 2-way repeated measures ANOVA or mixed effects analysis where appropriate ∗p < 0.05 ∗∗p < 0.01 ∗∗∗p < 0.001. Blood glucose levels before and after an oral gavage glucose tolerance test administered at (2gm/kg LBM) at 5 and (50mg glucose) age 9 months with corresponding area under the curve.
(G and H) Fasting blood glucose, (I and J) glucose excursion and (K and L) area under the curve at age 5 months in male and female mice.
(M and N) Fasting blood glucose, (O and P) glucose excursion and (Q and R) area under the curve at age 9 months in male and female mice. Male mice n = 6–8 per group, female mice, n = 6–7 per group. Fasting blood glucose was taken after a 6 h fast and is the ‘0’ time value represented in the OGTT curve. ∗p = <0.05 ∗∗p = <0.01 represent genotype effect between WT and 5xFAD∗Tg30 mice. Fasting blood glucose and AUC assessed by T-Test and glucose curves via repeated measure ANOVA. Graphs indicate mean ± SEM.