Figure 5.

Metabolic phenotyping of 5xFADxTg30 mice

Aspects of whole-body energy metabolism measured in a CLAMs system for WT control and 5xFADxTg30 mice.

(A–D) Respiratory exchange ratio (RER) in male and female mice during the light and dark cycles.

(E–H) Total movement/activity as measured via beam breaks (x + Y ambulatory plus z breaks) in male and female mice during the light and dark cycles.

(I–L) Raw oxygen consumption in male and female mice during the light and dark cycles.

(M–P) Oxygen consumption normalised to lean tissue mass in male and female mice during the light and dark cycles.

(Q–T) Energy expenditure (Heat), in male and female mice during the light and dark cycles.

(U–X) Energy expenditure (Heat) adjusted to lean mass in male and female mice during the light and dark cycles. Genotype effects in oxygen consumption rate, as well as energy expenditure in males. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p = <0.001 data assessed by a Student’s t test n = 5–8 per group. Graphs indicate mean ± SEM.