Figure 7.

Sex and genotype differences in plasma and brain lipid species between WT and 5xFADxTg30 mice

(A) Volcano plot showing changes in plasma lipids in male WT and 5xFADxTg30 mice.

(B–Q) Indicated lipid species in male WT and 5xFADxTg30 mice.

(R) Volcano plot showing changes in plasma lipids in female WT and 5xFADxTg30 mice.

(S–X) Indicated lipid species in female WT and 5xFADxTg30 mice.

(Y and Z) Volcano plot showing changes in brain lipids in male Y) and female Z) WT and 5xFADxTg30 mice. Data shown in B-Q and S-X was analyzed by un-paired t-test. Statistical significance (p value) is shown on each figure. Data in B-Q and S-X are shown as the mean ± SEM. Individual symbols represent biological replicates.