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. 2023 Dec 22;9(1):e00419-23. doi: 10.1128/msphere.00419-23

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Copyright © 2023 Shrivastava et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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Fig 5 — Shigella LPS-specific IgG and IgA contribute synergistically to bactericidal activity. (A) S. sonnei LPS-specific antibody isotypes in fecal supernatants from individuals at day 10 post-vaccination with 10⁷ CFU of either WRSs2 or WRSs3 (five individuals from each group). (B) S. sonnei LPS-specific antibody isotype in purified IgA and IgG preparations obtained from samples shown in panel A. (C) Fecal BA and (D) fecal OPKA titers of IgA, IgG, or a combination of IgA + IgG. Data represent individual samples (left) and means ± 95% CI (right). P-values obtained using Wilcoxon matched-pairs signed rank test are indicated in the graphs on the right. Dotted line indicates limit of detection (titer of 2 for BA and OPKA).