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. 2024 Jan 16;17:1296458. doi: 10.3389/fnins.2023.1296458

Table 1.

Post-noise hypothermia TTM accelerates recovery of ABR thresholds to baseline.

Recovery 1 DPN 3 DPN 7 DPN 14 DPN 28 DPN
kHz M SE M SE M SE M SE M SE
Noise – TTM Ck 37.5 7.3 ** 24.0 4.8 ** 18.3 4.6 ** 13.3 5.1 14.2 4.2
2 35.8 6.0 ** 16.0 5.6 * 13.3 4.8 10.8 4.2 9.2 4.0
4 38.3 4.2 ** 20.0 5.2 ** 15.8 3.7 * 9.2 2.4 12.5 1.1
8 46.7 3.3 ** 33.0 6.8 ** 35.8 7.2 ** 30.8 5.8 ** 35.8 5.2 **
16 50.0 1.8 ** 32.0 6.8 ** 25.8 5.1 ** 24.2 4.0 ** 22.5 7.2 **
24 45.8 3.0 ** 15.0 6.3 8.3 5.6 10.0 6.1 7.5 5.0
32 55.8 4.5 ** 32.0 4.1 ** 15.0 5.8 8.3 3.6 10.0 5.2
Noise + Normo. Ck 26.7 6.7 ** 24.2 5.8 ** 20.8 4.2 ** 16.7 4.2 10.0 4.7
2 20.8 7.0 ** 17.5 4.4 ** 18.3 3.3 * 15.0 3.4 5.0 5.3
4 38.3 6.9 ** 28.3 5.9 ** 21.7 4.8 ** 14.2 5.5 10.8 5.5
8 48.3 5.7 ** 35.0 8.9 ** 28.3 4.4 ** 23.3 6.5 ** 10.8 4.4
16 33.3 6.0 ** 21.7 4.4 ** 20.0 5.0 ** 14.2 5.2 5.8 3.5
24 35.8 9.0 ** 21.7 8.2 ** 10.8 6.5 10.0 5.0 5.0 4.1
32 43.3 7.0 ** 26.7 5.3 ** 14.2 4.5 8.3 4.4 5.8 2.4
Noise + Hypo. Ck 11.0 4.3 * 0.0 1.6 2.0 3.0 2.0 3.0 3.0 3.4
2 2.0 4.4 2.0 1.2 −2.0 3.4 −2.0 2.0 −2.0 2.0
4 3.0 2.5 1.0 1.0 2.0 2.0 0.0 1.6 1.0 2.4
8 21.0 4.0 ** 12.0 3.7 ** 8.0 3.4 7.0 4.1 5.0 4.7
16 13.0 5.1 ** 3.0 2.5 0.0 3.5 3.0 2.5 3.8 1.3
24 19.0 5.8 ** 2.0 2.5 2.0 3.0 0.0 1.6 −1.3 1.3
32 23.0 3.0 ** 4.0 3.7 3.0 2.0 1.0 1.9 2.5 2.5

Significance level.

** < 0.01, * < 0.05.

Summary of ABR threshold shifts from baseline obtained before and after exposure to 2 h of 105 dB noise. Results of mean ± SE ABR threshold shifts for noise only, normothermia, and hypothermia TTM animals are shown for all tested stimuli (click, 2–32 kHz). Group-specific statistical difference from pre-noise measurements was obtained at 1, 3, 7, 14, and 28 DPN (*p < 0.05, **p < 0.01). Significant values in bold. ABR Threshold Shifts up to 28 DPN. dB, decibels; Normo, Normothermia; Hypo, Hypothermia; DPN, days post-noise; Ck, Click; Mean ± SE.