TABLE 1.
Unadjusted proportions of patients ≥70 years of age with T1N0 HR+ breast cancer, by frailty status and life expectancy
| Frailty (total N = 16,188) | Life expectancy (total N = 16,188) | |||
|---|---|---|---|---|
| No (n = 12,664, 78.2%) | Yes (n = 3524, 21.8%) | ≥ 5 years (n = 12,603, 77.9%) | < 5 years (n = 3585, 22.2%) | |
| Patient characteristics | ||||
| Racea | ||||
| African-American/Black | 617 (4.9) | 300 (8.5) | 630 (5.0) | 287 (8.0) |
| Hispanic/Latinx White | 501 (4.0) | 184 (5.2) | 497 (3.9) | 188 (5.2) |
| Non-Hispanic/Latinx White | 10,812 (85.4) | 2899 (82.3) | 10,772 (85.5) | 2939 (82.0) |
| Other/unknown | 734 (5.8) | 141 (4.0) | 704 (5.6) | 171 (4.8) |
| Year of diagnosis | ||||
| 2010 | 2055 (16.2) | 548 (15.6) | 2025 (16.1) | 578 (16.1) |
| 2011 | 2161 (17.1) | 552 (15.7) | 2114 (16.8) | 599 (16.7) |
| 2012 | 2169 (17.1) | 615 (17.5) | 2138 (17.0) | 646 (18.0) |
| 2013 | 2220 (17.5) | 602 (17.1) | 2214 (17.6) | 608 (17.0) |
| 2014 | 2206 (17.4) | 642 (18.2) | 2243 (17.8) | 605 (16.9) |
| 2015 | 1853 (14.6) | 565 (16.0) | 1869 (14.8) | 549 (15.3) |
| Median incomea | ||||
| Quartile 1 (lowest) | 1536 (12.1) | 610 (17.3) | 1579 (12.5) | 567 (15.8) |
| Quartile 2 | 2484 (19.6) | 752 (21.3) | 2468 (19.6) | 768 (21.4) |
| Quartile 3 | 3426 (27.1) | 933 (26.5) | 3351 (26.6) | 1008 (28.1) |
| Quartile 4 (highest) | 5218 (41.2) | 1229 (34.9) | 5205 (41.3) | 1242 (34.6) |
| Charlson–Deyo Comorbidity Indexa | ||||
| 0 | 7045 (55.6) | 1105 (31.4) | 7103 (56.4) | 1047 (29.2) |
| 1 | 1777 (14.0) | 876 (24.9) | 1875 (14.9) | 778 (21.7) |
| 2 | 744 (5.9) | 588 (16.7) | 766 (6.1) | 566 (15.8) |
| 3 | 255 (2.0) | 332 (9.4) | 221 (1.8) | 366 (10.2) |
| ≥4 | 116 (0.9) | 437 (12.4) | 80 (0.6) | 473 (13.2) |
| Unknown | 2727 (21.5) | 186 (5.3) | 2558 (20.3) | 355 (9.9) |
| Urban/rural status | ||||
| Urban | 6422 (50.7) | 1758 (49.9) | 6288 (49.9) | 1892 (52.8) |
| Rural | 1251 (9.9) | 341 (9.7) | 1263 (10.0) | 329 (9.2) |
| Unknown | 4991 (39.4) | 1425 (40.4) | 5052 (40.1) | 1364 (38.1) |
| SEER regiona | ||||
| West | 5632 (44.5) | 1480 (42.0) | 5618 (44.6) | 1494 (41.7) |
| Northeast | 2564 (20.3) | 720 (20.4) | 2452 (19.5) | 832 (23.2) |
| Midwest | 1573 (12.4) | 408 (11.6) | 1536 (12.2) | 445 (12.4) |
| South | 2895 (22.9) | 916 (26.0) | 2997 (23.8) | 814 (22.7) |
| Disease characteristics | ||||
| Tumor grade | ||||
| 1 | 5110 (40.4) | 1382 (39.2) | 5138 (40.8) | 1354 (37.8) |
| 2 | 5993 (47.3) | 1658 (47.1) | 5931 (47.1) | 1720 (48.0) |
| 3 | 1193 (9.4) | 357 (10.1) | 1183 (9.4) | 367 (10.2) |
| Unknown | 368 (2.9) | 127 (3.6) | 351 (2.8) | 144 (4.0) |
| Tumor stagea | ||||
| T1a | 1690 (13.3) | 365 (10.4) | 1684 (13.4) | 371 (10.4) |
| T1b | 4564 (36.0) | 1182 (33.5) | 4600 (36.5) | 1146 (32.0) |
| T1c | 6410 (50.6) | 1977 (56.1) | 6319 (50.1) | 2046 (57.7) |
| Histology | ||||
| IDC | 9363 (73.9) | 2571 (73.0) | 9389 (74.5) | 2545 (71.0) |
| ILC | 1934 (15.3) | 542 (15.4) | 1926 (15.3) | 550 (15.3) |
| Other | 1367 (10.8) | 411 (11.7) | 1288 (10.2) | 490 (13.7) |
| Treatment characteristics | ||||
| No treatment | 490 (3.9) | 305 (8.7) | 400 (3.2) | 395 (11.0) |
| Low intensity | ||||
| Lumpectomy alone | 792 (6.3) | 434 (12.3) | 566 (4.5) | 660 (18.4) |
| Moderate intensity | ||||
| Mastectomy alone | 134 (1.1) | 68 (1.9) | 99 (0.8) | 103 (5.9) |
| Lumpectomy + axillary surgery | 2282 (18.0) | 692 (19.6) | 2247 (17.8) | 727 (20.3) |
| Lumpectomy + RT | 405 (3.2) | 185 (5.3) | 383 (3.0) | 207 (5.8) |
| High intensity | ||||
| Lumpectomy + axillary surgery + RT | 6097 (48.1) | 1162 (33.0) | 6392 (50.7) | 867 (24.2) |
| Mastectomy + axillary surgery | 2464 (19.5) | 678 (19.2) | 2516 (20.0) | 626 (17.5) |
p < 0.05 for differences within groups by frailty and life expectancy, respectively
HR+ hormone receptor-positive, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, RT radiation therapy, SEER Surveillance, Epidemiology, and End Results, other/unknown ethnicity patients coded as American Indian, Chinese, Japanese, Filipino, Hawaiian, Korean, Vietnamese, Laotian, Hmong, Kampuchean, Thai, Asian Indian, Pakistani, Micronesian, Chamorran, Guamanian, Polynesia, Tahitian, Samoan, Tongan, Melanesian, Fiji Islander, New Guinean, other Asian not otherwise specified, Pacific Islander not otherwise specified, other, or unknown in SEER