TABLE 1.

Effect of rhMPO on killing of C. albicans by resident macrophages

Addition of rhMPOa	rhMPO concn (U/ml)	C. albicans killedb (% of inoculum)
None		20 ± 6
Concomitant	0.8	22 ± 6
	1.6	28 ± 9
	3.2	36 ± 6*
Preincubation	3.2	32 ± 7*
Concomitant	6.4	35 ± 8*
Preincubation	6.4	33 ± 7*

^aIn concomitant conditions, MPO was added immediately before addition of C. albicans. In other experiments, as indicated, macrophages were preincubated with the concentration of rhMPO shown for 30 min at 37°C under rotation (4 rpm) and then centrifuged and washed twice with buffer. 

^bIncubation of macrophages (5 × 10⁶/ml) and preopsonized C. albicans (5 × 10⁶/ml) was performed under slow rotation (4 rpm) for 60 min. Data represent means ± SEM (n > 5). *, P < 0.05 compared with buffer control.