TABLE 2.

Effect of rhMPO on killing of C. albicans by rhGM-CSF-treated macrophages

Treatment of macrophagesa	rhMPO concn (U/ml)	C. albicans killedb (% of inoculum)
None		17 ± 8
rhGM-CSF		29 ± 5
	0.4	33 ± 7
	0.8	44 ± 6*
	1.6	54 ± 4**
	3.2	59 ± 7**
	6.4	57 ± 6**

^aAfter 72 h in culture, macrophages were preincubated with buffer or 200 U of rhGM-CSF per ml for another 48 h. 

^bIncubation of macrophages (5 × 10⁶/ml) and preopsonized C. albicans (5 × 10⁶/ml) was performed under slow rotation (4 rpm) for 60 min. Data represent means ± SEM (n = 6). Statistical significance was determined by comparing the killing of C. albicans by rhGM-CSF-treated macrophages in the absence and in the presence of rhMPO. *, P < 0.05; **, P < 0.01.